Hyperhomocysteinemia, Low Folate and Vitamin B12Concentrations, and Methylene Tetrahydrofolate Reductase Mutation in Cerebral Venous Thrombosis
نویسندگان
چکیده
منابع مشابه
Hyperhomocysteinemia, low folate and vitamin B12 concentrations, and methylene tetrahydrofolate reductase mutation in cerebral venous thrombosis.
BACKGROUND AND PURPOSE Elevated plasma levels of homocysteine are associated with an increased risk of deep-vein thrombosis. Through a case-control study, we examined the potential association among homocysteine, folate and vitamin B12 levels, and the common C677-->T mutation in the methylene tetrahydrofolate reductase (MTHFR) gene in patients with cerebral venous thrombosis (CVT). METHODS Fo...
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PURPOSE Portal vein thrombosis (PVT) is a rare and life-threatening vascular disorder characterized by obstruction or narrowing of the portal vein. Hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been studied in PVT patients with conflicting results. In the present study the association of hyperhomocysteinemia and MTHFR C677T polymorphism with PVT ris...
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Methylene tetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of homocysteine to methionine, and folic acid is an essential cofactor. Mutations in the MTHFR gene lead to hyperhomocysteinemia and vascular thrombosis. Heterozygous mutation involving a single nucleotide polymorphism in the MTHFR gene leading to vascular thrombosis is very rare. We present a case of segmental...
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Bilateral renal vein thrombosis secondary to methylene tetrahydrofolate reductase mutation: a rare case To the Editor, Renal vein thrombosis (RVT) is a rare but serious complication that is associated with many systemic disorders [1]. Thromboembolic complications, especially RVT, are frequent in nephrotic syndrome and are very prevalent in membranous nephropathy [1]. Trauma, oral contraceptives...
متن کاملMethylene tetrahydrofolate reductase genotype and the risk and extent of coronary artery disease in a population with low plasma folate.
OBJECTIVE To determine the effects of the thermolabile methylene tetrahydrofolate reductase (MTHFR) mutation on the presence and extent of coronary atherosclerosis in a population with low plasma folate. METHODS 242 consecutive patients undergoing coronary angiography were prospectively evaluated for conventional risk factors, plasma homocysteine, vitamin B-12, and folate, and MTHFR genotype....
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ژورنال
عنوان ژورنال: Stroke
سال: 2004
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000132570.24618.78